The agent-involved shooting was reported around 6 a.m. near 10100 Reflections Boulevard in Sunrise, Florida, according to the statement.
Authorities did not immediately release any information about the suspect, who reportedly remained inside the home, surrounded by officers.
"Two FBI Agents are deceased and three are wounded", the FBI said.
A law enforcement source told the Miami Herald that the suspect had shot and killed himself after barricading himself in his home for several hours.
The FBI said its Inspection Division is investigating the shooting. "The review process is thorough and objective and is conducted as expeditiously as possible under the circumstances".
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More officers have gathered outside a hospital where victims were taken.
Acting Attorney General Monty Wilkinson was briefed on the shooting and was closely monitoring the situation on Tuesday, a Justice Department spokesperson said.
Two caskets were seen draped with American flags and being taken into the Broward Medical Examiner's office around 10 a.m., WSVN in Miami reports.
The shooting is thought to be one of the deadliest in the FBI's history and the first to lead to the death of an agent since 2008. On April 11, 1986, two violent bank robbers being pursued by Federal Bureau of Investigation agents opened fire with high-powered firearms, killing two agents and wounding five others before the suspects were killed.
Police said there was a heavy police presence in the area of 4200 Nob Hill Rd. and that the street was closed in both directions.