The news was confirmed by the actor's family who said in a statement that she breathed her last on December 29 in Portland, Oregon. She apparently went to the bathroom and never came out. The results of her autopsy are still unknown.
The media outlet has reported that Jessica's aunt tried to revive her but was unable to, and neither could the EMTs when they arrived at the house.
Prior to her death, Campbell had been complaining about congestion and said she thought she was getting a cold.
According to Variety, Campbell retired from acting to become a naturopathic physician.
A GoFundMe page set up to cover the cost of her funeral revealed that she has left behind a 10-year-old son, Oliver.
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Jessica then became a guest star on hit TV series Freaks and Geeks. However, Campbell got her big break in 1999 when she starred in the satire film Election with Reese Witherspoon and Matthew Broderick. Our thoughts are with Jessica's loved ones during this hard time.
Witherspoon, whose character Tracy Flick went up against Tammy Metzler in the Election election, wrote that she is "so heartbroken" to hear the news.
Campbell also performed in the 2001 film The Safety of Objects with Glenn Close, Dermot Mulroney, Patricia Clarkson, Kristen Stewart and Joshua Jackson.
Apatow shared on Twitter that some of his "favorite memories of making Freaks and Geeks are of watching Jessica Campbell and @sethrogen figure their relationship out in improvisations", as she played tuba player Amy Andrews, a love of interest of Rogen's Ken Miller for two episodes in 2000.
Campbell forged a career in acting in the 1990s.