There were 26 further Covid-related deaths reported by the Department of Health today (Friday).
Meanwhile the latest official statistics show that the number of deaths related to Covid-19 has now passed 2,000 in Northern Ireland.
There are 1,182 cases in Dublin, 421 in Cork, 258 in Limerick, 187 in Galway and 164 in Waterford.
They said as of 2pm today, 1,854 Covid-19 patients are hospitalised of which 191 are in ICU.
A further 154 Covid-19 patients were admitted to hospital in the past 24 hours.
Validation of data at the Health Protection Surveillance Centre (HSPC) has led to one death and seven cases that were previously confirmed being identified, which is reflected in the current running totals of cases and deaths.
In a memo sent to Extra.ie, Dr Holohan said 'This virus has taken root in every single part of the country.
Speaking at the release of the daily case numbers, Dr Holohan said the now 1 in 10 of the population either have the virus or are a close contact of someone who has it. Too many people are still not complying as fully as we need with the advice.
"R is coming down but it is coming down from a very high level of number of cases so that decrease has to be maintained for a long period of time, for I would say, another two to three weeks before we can get those numbers of positive cases, before we can get the number of hospital admissions down so that we can really see the pressure starting to come off our hospitals and our health service". The UK variant is very likely making our challenge more hard.
25-year-old among 208 Covid deaths in Ireland this month with current situation now 'worse than Spring last year'
"To ensure our hospitals and loved ones remain protected, and stay alive to receive the vaccine, please continue to follow public health advice and stay home". The safest place at the moment is at home. "Please stay at home", he said.
The 14-day incidence rate per 100,000 of the population now stands at 1530.2. Within the past fortnight, 1,897 cases have been reported in Clare.
Elsewhere in Northern Ireland, there have been an additional 22 deaths and 705 new cases today.
"Due to the nature of the mutation found in the United Kingdom variant of the virus, it is inevitable that it will become the dominant variant here in Ireland over time".
"We have identified multiple different SARS-CoV-2 lineages in Ireland since the start of the pandemic, and two of the three recently emerged variants of concern from the United Kingdom and South Africa".
While Deputy Chief Medical Officer Dr Ronan Glynn said: "We have worked exceptionally hard in recent weeks to reduce our close contacts". It highlights the need for us all to protect one another by staying at home. "Do not attend illegal gatherings", he said. "Remember the simple and effective measures from springtime - wash your hands well and often, wear a mask, cough and sneeze into your elbow, keep 2 metres of space from others, and phone your GP at the very first sign of COVID-19 symptoms".
"Nobody predicted, in any model, the level of community transmission that we're now experiencing", Martin said.
Of these, 59 deaths occurred in January 2021.
The Chief Medical Officer says anyone who has travelled from Brazil in the last 14 days should self-isolate.
Coronavirus deaths reach new one-day high in the US
In the last 10 months, coronavirus deaths in the United States have topped 380,000, per Johns Hopkins data. Globally, there have been 1.6 million COVID-19 related deaths.