Ottawa is reporting 72 new cases of COVID-19.
The province reported 1,958 cases on Monday.
Twenty-five of the 49 new deaths were people living in long-term care (LTC) homes, according to provincial data.
There are now 253 long-term care homes and 153 retirement homes with an active outbreak of the virus across Ontario.
Another 63 people have died across the province with over 2,000 cases considered resolved. There are now 23,036 active cases of COVID-19, compared to more than 27,600 a week ago.
Trudeau noted that while the number of new cases linked to travel remains low, the bad choices of a few won't be allowed to put others in danger.
All three regions saw a day-over-day decrease in new cases today.
In the past 24 hours, the province processed 30,717 lab-confirmed tests, down from almost 36,000 tests a day ago.
Ontario Premier Doug Ford leaves the Terminal 1 International Arrivals area of Toronto Pearson International Airport on Tuesday, Jan. 26, 2021.
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Health Minister Christine Elliott said over 36,000 tests were completed.
And with 55,191 tests processed in the previous day, the province's COVID-19 positivity rate is at 4 per cent.
COVID-19 hospitalizations saw a notable jump compared to a day ago.
There are now 36 patients in Ottawa hospitals (up three from Tuesday Monday) and six patients are in intensive care.
Ontario is also reporting that 9,707 more doses of a COVID-19 vaccine have been administered since the last daily update.
"We have 30,000 people coming through the airport every week so if you do the math that comes to about 750 people who are arriving with the virus each week", he said. More than 229,700 people have recovered from the virus.
Of the positive tests, four have been screened as potential United Kingdom variant and will undergo further investigation.
Along with the South African variant, the new strains are believed to be about 50 per cent more transmissible than other variants of the virus.
The first shipment of a COVID-19 vaccine is scheduled to arrive in one of 31 fly-in First Nations communities on Tuesday as part of Ontario's Operation Remote Immunity. Two weeks ago, that number reached 3,479.