The FBI named Little "the most prolific serial killer in us history" previous year, and its analysts believe all of his confessions are credible, although some of the deaths originally were ruled accidents or overdoses.
The California Department of Corrections and Rehabilitation confirmed that Little died at age 80 at 4:53 a.m. on Wednesday at an outside hospital.
California corrections department spokeswoman Vicky Waters said there is no sign of foul play, and his cause of death will be determined by a coroner.
They also released images of the victims he drew while in prison in an attempt to trace those he killed. Some bodies have never been found, "said the Federal Bureau of Investigation on the website in question".
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This former boxer killed his victims, often isolated women from minorities, by striking them violently and strangling them.
Authorities have said he appeared to have targeted mostly vulnerable young Black women, many of them prostitutes or drug addicts, whose deaths were not well-publicized at the time and in some cases not recorded as homicides. At least one was transgender.
According to the CDCR, Little, who spent his life travelling the country making a living by boxing or crime, served two prior terms in a California state prison before he was convicted for the murders in 2014. In 2014, he was sentenced to three life sentences without parole. In 1984, he said he met a 25-year-old "hippie"-looking woman outside a strip club who asked him for a ride from Cincinnati to Miami".
In an interview in 2018 with The Cut, a web-based subsidiary of NY magazine, he said that killing his victims "felt like heaven".