The 29-year-old has been out of action since the middle of last month, when he was on the receiving end of a awful challenge by Jordan Pickford.
The Dutch colossus is in the first phase of his recovery after successful ACL surgery last month following his injury in the Merseyside derby draw.
Liverpool have issues in defence too as Trent Alexander-Arnold is set to miss the visit of Leicester due to a calf injury that he sustained before the worldwide break while Joe Gomez has been ruled out for most of the season with a knee injury.
The news will come as a significant boost to the Premier League champions, who are in the midst of a defensive injury crisis.
The ex-Real Madrid and Manchester United striker told talkSPORT: "It's when you get really tested because in some games, if you're in a good team that are better than the rest, you can carry one or two players that aren't quite at it".
Meanwhile the champions will take on log-leaders Leicester City this weekend at Anfield.
Henderson picked up a groin injury during during England's 2-0 defeat to Belgium in the Nations League on Sunday night and returned to Liverpool on Monday for assessment after pulling out of Gareth Southgate's squad ahead of the win over Iceland.
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Most recently, the star had something positive to celebrate, when she was awarded the Icon Award at the People's Choice Awards on Sunday evening.
"When you're in the tunnel before the game you look in front of you and behind you and think, "right, we've got a chance because we've got him in our team".
It would appear that Van Dijk's recovery is going well and the thought of him playing again this season is a wonderful one.
"A cruciate ligament injury is sort of five to six months if everything goes perfectly. It's a huge blow".
Alex Oxlade-Chamberlain, Trent Alexander-Arnold and Joe Gomez are amongst the Liverpool players who have been ruled out of action due to injuries.
Salah is out of Sunday's game after a second positive test for coronavirus while with the Egypt national team this week.
It is still unknown how long the Netherlands worldwide will be in recovery but former Liverpool striker and Ballon d'Or victor Michael Owen believes that the 29-year-old could be available during the key home-run period of the season.