The Citizens could hand UEFA Champions League debut to Nathan Ake when they face up with Olympiacos.
Having only recovered from a knee injury, the Argentine striker injured his hamstring in the draw with West Ham United and missed last Saturday's win at Sheffield United and the Champions League trip to Marseille last week.
With some pundits suggesting that Guardiola will rest players in Europe ahead of Liverpool's visit to The Etihad on the weekend, the Catalonian said: "It's the Champions League".
"It's too early to know, we'll see at the last training", Guardiola said. Olympiakos the same. They have to win every single game. The club from the Athens suburb of Piraeus have lost nine of their 10 Champions League games away to English clubs by a combined score of 30 goals to seven and in Manchester specifically, it's even worse: three losses to United at Old Trafford, no goals scored, 10 conceded.
It has strengthened his view that, even allowing for the manic schedule, Manchester City can not afford to take team selection risks in Europe.
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Guardiola said: 'He's getting better but right now I don't know.
"Every game is hard, people don't believe it", added Guardiola. 'It's a tricky competition. "With this situation around the world, everything is more uncertain for all the clubs". People say it's easy and they predict the teams who go through but anything can happen.
"We don't want to make a step back again but he's getting better", Guardiola said at a news conference on Monday.
"Tomorrow we have an incredible opportunity to take a huge step toward qualifying for the next round. We're awaiting Sergio but we've been happy with Ferran [Torres] so we have another alternative and he can play without a doubt in this position".