Van Dijk was in the Everton box in the sixth minute because of a corner, with Liverpool having already taken the lead, when Fabinho lifted the ball towards the far side of the box.
Liverpool thought they had won the game in injury-time, but Jordan Henderson's strike was ruled out after Mane was adjudged by VAR to have been offside by the tiniest of margins.
Everton kept their unbeaten record in the league this season as they are leading the table with 13 points from 4 victories and a draw. "We will see if it's true or not, but if he felt like this then we need to have a look".
The Netherlands centre-back was forced off after only ten minutes of the Merseyside derby after a late challenge by Jordan Pickford.
The German boss was delighted to see a positive reaction from his team after their 7-2 humbling at Aston Villa before the global break.
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However, Liverpool's afternoon turned sour when van Dijk limped off minutes later after being on the wrong end of a shocking challenge from Everton number one Pickford.
"It was probably the best away game since I am at Liverpool at Goodison". But Dominic Calvert-Lewin then added a second for Everton in the 81st minute, which assured that the spoils were shared.
Desperate to atone their 7-2 beating by Aston Villa in last league match, The Reds looked deserving to get three full points against Carlo Ancelotti's men.
That proved crucial as Calvert-Lewin produced an incredible leap and header from Digne's cross to level once more.
"I'm disappointed we didn't win the game and I know the fans are too", he said.
Pickford was not punished for the incident but Henderson insisted that Pickford was indeed apologetic and was genuine about it. The VAR did intervene this time, spotting Sadio Mane was offside by the narrowest of margins.