British Study Shows Antibodies Against COVID-19 Declined Rapidly


"It remains unclear what level of immunity antibodies provide, or for how long this immunity lasts". A separate arm of the programme, REACT-2, is using antibody finger-prick tests to monitor past infections across England. Their team developed organoids containing types of lung and colon cells that are known to become infected in people with COVID-19.

The participants did three rounds of finger-prick tests at home between June 20 and September 28, according to a news release from the Imperial College London. Dr. Subash Ghimire of Guthrie Robert Packer Hospital in Pennsylvania suggested that patients with diarrhea may have higher viral loads, which can potentially lead the body to fight back with more severe responses.

Following new data from Imperial College London (ICL) suggesting that antibody levels against SARS-CoV-2 wane over time; Michael Breen, Director of Infectious Diseases and Ophthalmology at GlobalData offers his view.

In the first round of testing at the end of June and beginning of July, around 60 in 1,000 people had detectable antibodies, compared with 44 in 1,000 in the latest round of testing.

Now, new data has been released ahead of peer-review that shows after a second round of testing antibody levels dropped to 4.8 percent, and a third round showed that for those tested between September 15 and 21, the number dropped again to 4.4 percent.

In their findings, the researchers' analysis of the home finger-prick tests found that the number of people testing positive for antibodies dropped by 26.5% during the study period, from nearly 6% to 4.4%.

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Kroger announced Wednesday it will soon begin offering COVID-19 rapid antibody testing at all of its pharmacies - starting now in two states.

However, recently, a study from Imperial College London found that antibodies against Covid-19 declined rapidly in the hundreds of thousands of people across England.

Alexander Edwards, from the University of Reading, says decreasing antibody levels are not necessarily the same as losing immunity, pointing out that antibody levels naturally decrease as people recover from an infection.

Nonetheless, the authors of the Imperial report suggested that falling levels of antibody prevalence could indicate falling population immunity, given evidence from other human coronaviruses.

Study findings are based on a dataset of 30,082 individuals, who were screened within the Mount Sinai Health System between March and October 2020. "We know antibodies are important, but they're not the whole story", said Lawrence Young, a professor of molecular oncology at Britain's Warwick University.

"But we also know that other immune mechanisms kick in, including T cell immunity, lymphocytes, and white blood cells that target the virus and various other things, but we know less about these other immune mechanisms than we do antibodies at the moment".