Brazil's COVID-19 vaccine volunteer dies, authorities say trial to continue

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The trials of the vaccine AstraZeneca will continue as per the schedule.

Zaks confirmed to the London-based medical journal that Moderna's trial will not show prevention of hospitalization because the size and duration of the trial would need to be vastly increased to collect the necessary data.

Unfortunately, we still do not have a definitive answer as to when a vaccine against COVID-19 will be available.

The first teen to receive an injection was 16-year-old Katelyn Evans who is participating in the Pfizer study at Cincinnati Children's Hospital, according to the newspaper.

Pfizer said it may have an ethical duty to inform at least some study volunteers that they have been given a placebo.

J&J is a step behind after its USA trial was paused earlier this month due to an illness in a study participant. "We know a good portion of the USA public is skeptical of these vaccines and not jumping to take them once approved, at least at present", Hilary D. Marston, medical officer and policy adviser for pandemic preparedness at the National Institutes of Health.

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Moderna said it had now signed up all 30,000 participants for the phase-3 trial, and more than 25,000 of them had already received a second dose of the vaccine, four weeks after the first.

If the number of vaccinated participants contracting Covid-19 is at least 50 percent lower than in the placebo group, United States drug authority FDA can grant it emergency use authorization.

If the frail elderly is not enrolled into vaccine trials in sufficient numbers to determine whether there is a reduction in cases in this population, "there can be little basis for assuming any benefit against hospitalisation or mortality, " he warned. Health officials and those leading the study have not confirmed whether the volunteer had received the experimental vaccine or a placebo prior to his death.

Brazil has been one of the hardest-hit areas of the world during this pandemic. No further information about the volunteer who has died and others under test are not revealed, as it the duty to maintain confidentiality of the volunteers.

Normally when a study ends because of evidence that a vaccine is working, the participants who got dummy shots are offered the real thing.

Professor Trudie Lang, director of the Global Health Network at the Nuffield Department of Medicine explains, "The sad event of someone dying on a vaccine trial immediately triggers the actions defined in the trial protocol that are carefully set out for all serious events".

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