AstraZeneca resumes US COVID-19 vaccine trial, optimism seen for J,J By

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Doshi, an assistant professor of pharmaceutical health services research at the University of Maryland School of Pharmacy, said: "None of the trials now underway are created to detect a reduction in any serious outcome such as hospitalisations, intensive care use, or deaths".

AstraZeneca company is one of the leaders in the COVID-19 vaccine race.

The biotech company also touted the diversity of its trial population, with participants from minority groups represented in the overall group.

Several vaccines being developed and tested for COVID-19 are DNA-based, which uses a novel technique called DNA immunization to stimulate humoral and cellular immune responses to protein antigens efficiently.

Dr. Stephen Hoge, Moderna's president, said the clinical trials must hit three benchmarks before the company can apply to the FDA for emergency use authorization, CNN reported. Although temporary halts are common, the interruption raised concerns about the prospects of one of the fastest-moving shots and highlighted the hurdles researchers face when developing a vaccine.

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The Butantan Institute said on Monday that preliminary results from late-stage clinical trials of CoronaVac on 9,000 volunteers have proven that the two-dose Chinese vaccine is safe. "We would also like to thank the investigators and our partners at clinical trial sites, including our partners from PPD and the NIH, as well as the dedicated Moderna team for their support in completing enrollment", said Stéphane Bancel, CEO of Moderna, in the release. These efforts require that we re-engage the public, community leaders, health care providers, public health practitioners, policymakers and health authorities to address the challenges associated with building vaccine-related knowledge, attitudes and behaviors.

In the US, Moderna Inc., Johnson & Johnson and Novavax all hope to begin some pediatric research later in the year, in varying age groups.

In Turkey, participants who believed that the virus was human-made (artificial), were 54% more likely to be vaccine-hesitant.

Some pediatric vaccine experts say drugmakers and federal regulators should wait until the vaccines have been proven safe and effective in adults before moving to children.

Spahn said he wanted to set up a digital appointment system to organise the vaccinations, as well as an app to record possible side-effects. Still, the 12-year-old said he's happy to do his part if it means saving lives. Because most people with symptomatic Covid infections experience only mild symptoms, even trials involving 30,000 or more patients would turn up relatively few cases of severe disease. Along the way, we've encountered the normal what I would say scientific obstacles that had to be overcome.

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