The Champions League finalists confirmed that Neymar had tested positive in medical checks carried out as the team returned to training this week, meaning the most expensive player in history will be moved into isolation.
They went on to win both domestic cups in the space of a week but were denied an historic quadruple after losing 1-0 to Bayern Munich in the Champions League final on August 23.
The club said in a statement that the three players are now "subject to the appropriate health protocol" and that the rest of the squad and coaching staff "will continue to undergo tests in the coming days".
However, media outlet L'Équipe and ESPN say sources have confirmed the 28-year-old Brazilian superstar is one of the players who tested positive. along with his PSG teammates Angel Di Maria and Leo Paredes.
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Neymar and his friends tested positive for the coronavirus disease after returning from a holiday in Ibiza.
The French domestic season is already underway but PSG are yet to play due to their run to the Champions League final.
PSG, France's richest club, have played five competitive games in the last six months.
Positive tests have already disrupted the start of the new season, with the opening match of the campaign between Marseille and St Etienne postponed when Marseille reported four positive tests.