Charles Leclerc kept Ferrari's head up for their 1,000th world championship grand prix, qualifying fifth at a track owned by the Italian team who are struggling after two dismal performances at Spa and Monza.
A slow start for Hamilton at the start of the race provided Bottas with the opportunity to storm past Hamilton, before the Briton made amends at the second start by sweeping back into the lead at Turn 1.
Haas driver Kevin Magnussen was also caught up in the accident with all four cars sent into the barriers.
"It's definitely not a nice feeling to do 280kph and suddenly find three cars in the middle of the straight".
"The crash was properly scary", said Sainz, who collided with both Magnussen and Giovinazzi amid huge closing speeds.
"That was (expletive) stupid from whoever was at the front", he shouted.
'Keeping that over one-second gap was crucial as I didn't want them [race rivals] to have DRS on that 1000m straight.
"It's crazy but I don't know if people are able to see on TV, you go through Turns 6,7,8,9 at like 170-180mph and the G-Force you are pulling through there is insane".
A perplexed Bottas asked Mercedes what had happened after the restart.
With a red flag deployed for the second week in a row while the debris was cleared, Hamilton swept past Bottas from a grid restart and quickly built a commanding lead.
Update: Ocon failed to make the restart due to a brake issue, leaving just 13 cars in the race.
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Hamilton held firm and Bottas is now 55 points behind Hamilton, who is odds on to equal Schumacher's record of seven F1 titles.
In a poignant moment before the race start, Schumacher's son Mick drove his 2004 Ferrari around the Mugello circuit in honor of Ferrari's most successful driver.
Although indirectly, Valtteri Bottas will suffer the consequences of the strategy which led to a second game, as Lewis Hamilton returned the "kindness" to the Finn, taking advantage of Bottas' air cone to pass his teammate in the first corner.at the second departure of the day.
On a glorious day in the Tuscan hills, the air temperature was 29 degrees Celsius and the track 46 as Q1 began with Bottas topping Hamilton by nearly three-tenths, leaving Verstappen adrift by half a second in third.
"We are all athletes and we train, but this track is incredibly physical and it is not at all easy to go through that fast section", said Hamilton.
"This track is just phenomenal", he said.
"My heart is racing". "It is insane to be here and to have 90 grand prix (wins)".
But Hamilton's focus was elsewhere as he stood on the podium wearing a T-shirt featuring the words "Arrest the cops who killed Breonna Taylor".
The F1 circuit next moves on to Sochi in Russian Federation in a two weeks, a race won four times in the past by Hamilton, including a year ago.
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