"Some politicians have ignored the most basic facts and concocted too many lies about China and plotted too many conspiracies", he added.
China remains prepared to work with the United States in the spirit of cooperation and mutual respect, Wang said, when asked if Sino-U.S. relations would further worsen.
China plans to impose legislation on the semi-autonomous city that bans treason, subversion and sedition, officials said in response to months of massive, often-violent pro-democracy protests in the financial hub previous year. "Both sides should take this lesson to heart".
"This unsafe attempt to turn back the will of history will undo the fruits of decades-long China-US co-operation, dampen America's own development prospects, and put world stability and prosperity in jeopardy", Mr Wang said.
This was the first time a top diplomat and state councilor of China formally responded to senior USA officials and politicians' provocative and stigmatizing words and acts, said Chinese analysts.
He also said China does not have ulterior political motives or an intent to gain economic benefits by sending medical supplies and doctors overseas.
United States lawmakers have advanced several pieces of legislation targeting China in recent weeks with bipartisan support amid mounting calls for lawmakers to punish Beijing for its alleged failure to disclose information early on about the spread of Covid-19.
"China is open to working with the worldwide scientific community to look into the source of the virus", Wang said.
Oxford COVID-19 Vaccine to Begin Next Phases of Human Trial
Thomas' Hospital, have started clinical trials of a drug called interleukin 7 to test its effects on combating COVID-19. Every new technology is being applied for making COVID-19 vacines, he said.
However, the diplomat also made several jabs at Washington, telling reporters that Trump's administration is tarnishing relations with Beijing with what it calls a smear campaign.
"We have seen some positive steps taken by the DPRK in the last few years towards de-escalation and denuclearization", Wang said.
Foreign policy experts both within and outside China have criticised these diplomats, pointing out that the aggressive attitude has only served to strain ties further with the USA and affected Beijing's global image.
Mr Pompeo said earlier this month that there was "a significant amount of evidence" that the virus came from a laboratory in Wuhan. "It's kind of a microcosm in where we are in the world in terms of great power competition between the U.S. and China".
Efforts should be made to stop the risky practice, he said.
He went on to say that Chinese medical teams are cooperating with their African counterparts, noting that around 400 training courses on means to combat the epidemic have been organized with African states.
The agency's Director-General Tedros Adhanom Ghebreyesus, elected with a majority of votes, has the full confidence of the global community, said Wang.
Wang added that with help from China and the rest of the world, the youthful continent of Africa will achieve greater and faster development after defeating COVID-19.