They were both hospitalized on January 25, she with a "mild cough" and he with pneumonia, the National Health Agency said.
A man in the Philippines died of the virus on Sunday, marking the first confirmed coronavirus death outside China.
The US will begin directing all flights from China to seven major airports where passengers can be screened for illness from today.
The fatality is a Chinese man from the city of Wuhan, where the virus was first detected.
China has locked down Wuhan and surrounding cities in a bid to contain the virus, but it has continued to spread.
Since emerging out of the central Chinese city of Wuhan late a year ago, the coronavirus has infected almost 14,500 people across China and reached 24 countries.
Thailand has announced 19 confirmed infections.
China's death toll from the outbreak reached 304 as of the end of Saturday, state broadcaster CCTV said on Sunday, citing the country's National Health Commission.
"Foreign nationals, other than immediate family of U.S. citizens and permanent residents. will be denied entry into United States Health Secretary Alex Azar had announced".
Stocks open higher on Wall Street; China's main market dives
Eight of the 11 primary S&P 500 sectors traded in green territory, with materials adding 2.13 percent, leading the gainers. The Dow and the S&P 500 reportedly experienced "their worst day since October", Monday, and airline stocks dropped.
The death was reported hours after Philippine's President Rodrigo Duterte was to issue a travel ban on all non-Filipino citizens from China, including Hong Kong and Macau.
The country is facing mounting isolation as other countries introduce travel curbs, airlines suspend flights and governments evacuate their citizens, risking worsening a slowdown in the world's second-largest economy.
Infections have also been reported in more than two dozen other countries and territories, including Australia, Britain, France, Germany, Hong Kong, Japan, Russia, Spain, Thailand and the United States.
Washington has "unceasingly manufactured and spread panic", Foreign Ministry spokeswoman Hua Chunying told reporters, noting that the World Health Organization had advised against trade and travel curbs.
USA citizens who have been to China in the last two weeks will have to be rebooked to seven gateway airports, including Los Angeles International Airport, Seattle-Tacoma, San Francisco, Chicago O'Hare, Hartsfield-Jackson Atlanta, John F. Kennedy in NY and Daniel K. Inouye in Honolulu.
China's government insists it can contain the virus and called USA advice against travel to China "unkind".
All the new deaths were from Hubei province, epicentre of the global outbreak, and which reported 1,921 new infections early Sunday.
The virus emerged in December in Hubei's provincial capital Wuhan, and has been traced to a meat market that sold wild game.
The number of confirmed cases in China has surpassed the number in the 2002-03 outbreak of Sars (Severe Acute Respiratory Syndrome).