Japan now has 45 virus cases.
But U.S. Treasury Secretary Steven Mnuchin said he still expected China to maintain its commitment to boost purchases of American goods and services by at least $200 billion over the next two years, as part of a Phase 1 trade deal.
"At present, they are being treated in isolation wards", the health ministry said.
Chuang said the three other cruises involved more than 5,000 passengers who had returned to Hong Kong.
In China, sometimes dubbed the world's workshop, cities have been shut off, flights cancelled and factories closed, shutting supply lines crucial to worldwide businesses. These include Hyundai, Tesla, Ford, PSA Peugeot Citroen, Nissan and Honda Motor Planemaker Airbus has prolonged a planned closure of its final assembly plant in Tianjin, China, it said.
Financial analysts have cut their growth outlook for the world's second-largest economy, with ratings agency Moody's pointing to a risk to auto sales and production. A 35-year-old man in Seattle, who was the first reported case in the USA, has recovered and is now at home.
The virus has shut down cities and factories in China and disrupted global air travel.
The overall confirmed cases on the Chinese mainland had reached 28,018 by the end of Wednesday, the commission said, noting that a total of 563 people had died of the disease.
After Britain advised nationals to leave China, Beijing's ambassador to London said there should not be "such a panic".
Several countries, including the United States, have banned entry to visitors who have been in China over the previous two weeks.
News of another virus hot spot emerged, linked to a mid-January company meeting in Singapore.
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Despite official insistence that life outside the main quarantine zones is "normal", Chinese people interviewed by the Telegraph across the country have complained they are subject to severe restrictions on their movements.
"A relatively mild virus can cause a lot of damage if a lot of people get it", Michael Ryan, director of the WHO's emergencies program, said at a briefing on Wednesday.
On Tuesday, health officials in Hong Kong cautioned there was growing evidence of neighborhood transmissions - instances where individuals have gotten infected with no traveling to China.
Global Times first reported Dr Li's death on Thursday evening, but later published a report from Wuhan Central Hospital that said his heart had stopped beating at 9:30pm (local time) and he was given resuscitation treatment and was in a critical condition.
Provincial health officer Bonnie Henry said the new patients are a man and woman in their thirties. That triggered a rush for the HIV drug.
Tests were still pending on others on board who had symptoms or contact with infected people.
"When you are left alone, seeing the blur shadow of death far away, I think no one can feel calm", Devy told Reuters.
With no reliable cure found for the virus, the World Health Organization will also convene a meeting of experts in Geneva next Tuesday and Wednesday to discuss treatment and vaccine development.
Even the overall number of confirmed Wuhan virus cases was vastly different, with the Tencent website allegedly listing a total of 154,023 cases, ten times higher than the official numbers.
Since the initial outbreak, coronavirus infections have been confirmed in nearly 30 countries outside of China.
More than two dozen airlines have suspended or restricted flights to China and hundreds of foreigners have been evacuated from Wuhan and placed in quarantine around the world.
Li was among a number of medical professionals in Wuhan who tried to warn colleagues and others when the government did not, the New York Times reported earlier this week.