Tottenham Hotspur striker Harry Kane will undergo surgery on his injured hamstring and is not expected to return to training until April.
"The striker suffered the injury during our Premier League fixture against Southampton last week and specialists have advised surgery after further review of the injury".
The London club have scored 359 times across his Premier League matches since 2014-15, an average of 1.9 per game.
The 26-year-old suffered the injury during Spurs' defeat at Southampton on New Year's Day, and specialists recommended that an operation was needed.
Chelsea will worry about their porous defence and questionable home record, but Spurs have still won only two league games away from home since beating Fulham at Craven Cottage on January 20 past year - and could desperately do with Kane to improve that record.
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Lucas Moura and Son-Heung Min partnered each other in attack against Middlesbrough, but could only muster one goal against Championship opposition as they were held to a disappointing draw.
Losing Kane is like ripping the soul out of this Spurs team.
Spurs will be without their talisman for both legs of the Champions League round of 16 tie against RB Leipzig and crucial Premier League clashes against Liverpool, Chelsea and Manchester United.
England are due to play friendlies against Italy and Denmark in March and boss Gareth Southgate will now be without his captain for those warm-up games.
England score a hugely impressive average of 2.3 goals per game - 103 in total - when the top scorer in Euro 2020 qualifying is involved.
Tottenham were already struggling to finish in the top four in this season's Premier League with Kane in the side, so Mourinho really has his work cut out now.