Suarez scored a free-kick from outside the box to give his side the lead before Messi's late intervention.
Meanwhile in the UEFA EURO Qualifiers Spain beat Romania 5-0 while Italy thrashed Armenia 9-1.
And after Luis Suarez put Uruguay back in front from a set-piece, Messi's persistence paid off after Martin Caceres had been harshly penalised for handball in the box.
It was not immune from politics - midway via the primary half the United States of America introduced it now not thought of Israeli settlements within the West Financial institution unlawful, a transfer condemned by the Palestinian management.
In the build-up to the game Uruguay coach Oscar Tabarez said he had been "very worried" about the game after a flare up between Israel and militant groups in neighbouring Gaza last week.
Organisers dubbed it as a game about peace, but boycott campaigners called for it to be cancelled over Israel's treatment of the Palestinians.
Former Massachusetts Gov. Deval Patrick announces presidential bid
Another Democrat - former New York City mayor Michael Bloomberg - is also weighing a last-minute bid for the party's nomination. Patrick's announcement, which he had signaled this week , came in the form of a video he released early Thursday morning.
The key to playing was in the guarantees presented by the Israeli authorities: "We had the information that the security was guaranteed with the ceasefire which began in Thursday".
"In bringing perhaps the world's most famous athlete, Lionel Messi, to Israel, we are providing excitement for the entire country - for Muslim, Christian and Jewish citizens of Israel", he stated in a press release to AFP.
Israel considers Jerusalem its "indivisible" capital, whereas Palestinians declare the jap a part of town - occupied by Israel in 1967 and later annexed - because the capital of their future state.
With Uruguay leading at the time thanks to a Cavani goal, Messi reacted angrily to a foul from combative midfielder Matias Vecino.
The soccer fans in the stands of the Tel Aviv stadium were biased toward Messi as they cheered for the Argentine skipper throughout.
During the first half of the match, Leo Messi went on another one of his trademark runs and took on nearly the entire opposition defence.
Three days after marking his return from a three-month worldwide ban by scoring the victor against Brazil, Messi once again underscored his value to his country.