USA troops on Friday also resumed patrols near oil fields in northeastern Syria after an intermission following the launch of Turkey's anti-terror Operation Peace Spring.
It follows an agreement they signed in the Black Sea resort of Sochi last week which gave Kurdish forces 150 hours to withdraw from a band of territory along Syria's border with Turkey, in a process that Russian Federation said was now complete.
The ministry blamed Syrian Kurdish fighters for the attack, saying it harshly condemns it and called on the worldwide community to take a stance against this "cruel terror organization".
The Britain-based Syrian Observatory for Human Rights reported that Saturday's explosion killed 14 civilians and Turkish-backed rebels.
Ankara views Syrian Kurdish fighters as "terrorists", and wants to expel them from areas along its southern border.
United Nations Secretary General Antonio Guterres said he would "consider the proposal", stressing the need for the "voluntary, safe and dignified" return of refugees, during a visit to Istanbul on Friday where he met with President Recep Tayyip Erdogan.
White House responds to Chile's announcement
Chile's cancellation of the trade summit caught the Trump administration by surprise, a White House official told Reuters . It came just days before Trump is expected to formalize his government's withdrawal from the Paris Agreement on November 4.
People check the destruction after a vehicle bomb exploded in Tal Abyad, Syria, Friday, Nov. 2, 2019. The town was captured last month by Turkish forces.
The SDF have been a key U.S. partner in fighting the Islamic State jihadist group, backed by air strikes by a US-led coalition.
After an abrupt and widely criticized decision by President Donald Trump to withdraw American troops from this part of Syria, the Kurdish forces approached the Syrian government and Russian Federation for protection. The Observatory said an American force arrived Saturday at the village of Himo west of Qamishli to set up the post.
The SDF expelled IS jihadists from their last patch of territory in Syria in March.
American troops heading toward the Iraqi border have been attacked from land held by Turkish-backed militants in northern Syria, Russia's Ministry of Defense has claimed.
But the USA had partnered with the Syrian Kurdish fighters, their top allies in the war against the Islamic State group.
Syria's war has spiraled into a complex conflict involving word powers since it started in 2011 with the brutal repression of anti-government protests.