Ron Carey, 80, strayed on to the M23 motorway and collided with a lorry while taking part in Sunday's rally.
Surrey Police said they wouldn't confirm any details about the victim, but confirmed that an 80-year-old man had lost his life in a crash.
A vintage vehicle driver has died in a crash with a lorry while taking part in the London to Brighton veteran auto run.
The man was driving his 1903 Knox Runabout Old Porcupine during the annual London to Brighton run, but was involved in a collision with a lorry after getting on to the motorway at about 10am.
Carey's wife Billi was also in the 116-year-old vehicle when it crashed and was airlifted to a nearby hospital with injuries, according to The Telegraph.
Surrey police confirmed the man's death in a statement, adding that the next of kin had been notified and asking anyone who witnessed the collision to come forward.
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His female passenger was seriously injured and taken to hospital.
"The driver died in the collision and the passenger was swiftly evacuated to hospital by the emergency services".
Around 400 cars took part in the rally. This year, nearly 90 percent of competitors made it to the finish line before the 4.30 p.m. deadline to claim a finishers' medal, organizers said in a news release. It is the longest-running auto event in the world, and starts in Hyde Park, London; runs down the old A23 road; and finishes in Preston Park in Brighton.
A spokesman for the event told The Telegraph that the vehicle had left the route and police were investigating the accident. It raised the speed limit of "light locomotives" from four to 14 miles per hour and abolished the need for a man to walk ahead of moving cars waving a red flag, according to run organizers.
A spokesman for the Veteran Car Run said: "The car involved in this morning's tragic incident on the M23 had been entered in the London to Brighton Veteran Car Run".
The auto is An 80-year-old man this weekend in London, died after he crashed his vehicle in 1903.