The serious respiratory illness has prompted a health scare that has led USA officials to urge people to stop vaping, especially with products containing THC.
They called for measures including restrictions on the accessibility and availability of vaping products, reducing the appeal of products to youth, including plain packaging, health warnings and regulating the sale and marketing of vaping products and flavourings, and putting in place school and community policies to reduce use.
Mitch Zeller, director of FDA's Center for Tobacco Products, said the agency has tested 225 THC-containing products and found Vitamin E acetate - a cutting agent - in almost half of them.
The guidance comes after MI announced the state's first death from vaping-related lung injury last week.
Adults who are vaping should not smoke combustible cigarettes as a replacement for nicotine.
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"I am very concerned that we continue to see new cases of vaping-related lung injury and this outbreak of illnesses and deaths appears to be far from over", said DPH Commissioner Renée D. Coleman-Mitchell. E-cigarettes are not FDA approved as a smoking cessation device.
More deaths are under investigation, according to the CDC.
The CDC, US Food and Drug Administration, state and local health departments, and other clinical and public health partners are continuing to investigate the multistage outbreak.
The two new deaths bring the total number of vaping-related deaths in the state to three since September 6, according to the Indiana State Department of Health. However, the ISDH said some individuals have reported vaping only nicotine.
"Unfortunately, MDHHS is not seeing a decrease in the number of cases being reported", noted a press release from the department. The majority of cases have occurred in people between 16 and 29 years old. Cases of lung injury have been reported in 49 states, the District of Columbia and one US territory.