Previously, Aguero who is Premier League joint top scorer alongside Chelsea's Tammy Abraham on eight goals, was involved in a vehicle collision.
City, though, have been weak in defence and have lost twice already this term.
Man City will desperately need their talisman as they look to keep up with rampant league leaders Liverpool - who have no opened up an eight-point gap.
The Argentine striker, 31, is said to not be hurt after the incident, however his £150,000 Range Rover was left in a mangled wreck.
The Argentinian striker's image shows the driver's side front wheel nearly horizontal, while the wheel arch and front bumper sustained significant damage.
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Images have emerged online allegedly showing the damage to Aguero's auto.
City boss Pep Guardiola will be relived his top scorer emerged unscathed from the accident.
Aguero will now turn his attention to being fit for this weekend's clash with Crystal Palace.
However, Argentina coach Lionel Scaloni has suggested the forward is not quite at full fitness.
The 31-year-old Argentina worldwide has once before been involved in a auto crash, with an incident in Amsterdam two years ago leaving Aguero with broken ribs.