Authorities said they feared the fire, which was caused by a tree branch that fell on power lines, could spread because of the strong winds expected to last through Thursday evening.
Dramatic dashcam video released by the Los Angeles Fire Department shows a white electrical arc and explosion along the side of Interstate 405, not far from The Getty art museum.
The race to stop an inferno torching the Los Angeles area has gotten more unsafe as furious winds - some as strong as in a hurricane - stoke the flames. Thousands of people who live in Brentwood are still under evacuation orders. "Investigators are working to determine the ownership of the land occupied by the tree".
As of Tuesday morning, the Kincade fire had burned more than 74,000 acres and was only 15 percent contained.
The Reagan Library is home to hundreds of artifacts and interactive displays about the 40th US president, and includes replicas of the White House's Rose Garden and White House South Lawn.
"The fire outflanked us very rapidly today, pushed by those 40 to 50 miles per hour (64 to 80 kph) winds", with gusts up 65 miles per hour (105 kph), fire incident commander Chad Cook said.
"It does take one ember, just one ember downwind, to start another brush fire", Los Angeles Fire Department (LAFD) Chief Ralph Terrazas has warned. The portion of the library housing archives faces away from the fire.
The Los Angeles County Fire Department was sending Firehawk water dropping helicopters and two strike teams to Simi Valley as part of its mutual aid agreement.
The strong Santa Ana winds are the result of a combination of high pressure and frigid, dry air from Canada.
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The couple has no relation to Kamille's family, police said. "We believe this was something they thought about and acted upon". An Amber Alert was quickly issued and police asked the public to be on the lookout for a dark-colored Toyota Sequoia.
In Northern California, where firefighters struggled for a sixth day against a 76,000-acre (30,760-hectate) blaze in Sonoma County's winemaking region, high-wind forecasts prompted Pacific Gas and Electric Co to impose a new round of blackouts for almost 600,000 homes and business. The National Weather Service warned that the conditions will be as risky "as we have seen in recent memory".
Neves lives in a voluntary evacuation zone.
He added, "There's a whole lot of heroes protecting the president's library".
In Northern California, the Kincade Fire has grown to almost 77,000 acres, but is now 30 percent contained, officials said.
The Kincade Fire started October 23, but the cause is still under investigation.
At the fire's height, evacuation orders were issued affecting 10,000 structures, both residential and commercial, in an area between the San Diego Freeway and Temescal Canyon Road, from Sunset Boulevard north to Mulholland Drive. About 7,000 homes, or around 26,000 people, were ordered evacuated, authorities said.
The arrival of high winds across the state mean that more than 2 million Californians could once again lose power amid concerns by utility companies over wind-blown equipment sparking wildfires.
Early Wednesday, PG&E announced that it had restored about 73 percent of the 970,000 or so customers affected in earlier shutoffs.