Kensington Palace announced that Prince Harry and Meghan Markle, Dutchess of Sussex, would leave the Royal Foundation later this year and it will become the "the principle charitable and philanthropic vehicle for The Duke and Duchess of Cambridge".
The Royal Foundation said both couples will continue to work together on projects in the future, particularly Heads Together.
"Thank you, everyone, for your lovely wishes on the Duke of Cambridge's birthday" Kensington Palace tweeted, using William's official title.
Royal author Katie Nicholl claims that the Duke of Cambridge's "well-meaning, brotherly advice went down quite badly with Harry, who felt William wasn't being as supportive as he might have been". Middleton joined the foundation after marrying into the Royal Family, as did Markle.
The Royal Family Twitter account, which shares updates on the Queen and other senior members, celebrated William's birthday by sharing a collage featuring several images of the prince from different stages of his life with his grandmother, Queen Elizabeth, and his wife, Kate Middleton.
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The news comes after Harry and Meghan moved out of Kensington Palace and into Frogmore Cottage in Windsor.
Harry and Markle replied in the comments.
The royal dad of three and second-in-line to the British throne is celebrating his 37th birthday Friday.
They added that the "Sussexes have a little more freedom and flexibility".
The body set up successful charity campaigns including Heads Together, the Endeavour Fund and projects with the Invictus Games.
The couples only appeared once together at the Royal Foundation's first Q&A forum in February 2018, which led to them being dubbed 'The Fab Four'.
"Not only will their new foundation stand the test of time, but it will allow them to do some very ambitious things".