An off-duty Virginia trooper reportedly saw the strike happen. Troopers haven't yet released the name of the man who was in the crash.
A Florida Highway Patrol spokesperson is cited as describing the helmet as shattered.
FHP Orlando shared a photo of the motorcyclist's helmet after the incident.
The 45-year-old North Carolina man was driving south bound on Interstate 95 when he was struck, ABC News reported Monday. "Unfortunately he did not survive the crash". Law enforcement were able to reopen one of the lanes to cars just before 3 p.m.
Thiem rides the storm to beat Djokovic in French semi-final
World number one Djokovic had been targeting a Grand Slam sweep for the second time in his career coming into the tournament. However, the Austrian won their most recent meeting on clay in the semi-finals in Barcelona in April in straight sets.
He was pronounced dead at the scene in east-central Florida.
According to the National Weather Service, it's the metal roof and metal sides on vehicles that keep them safe from lightning.
Out of the estimated 25 million strikes that make land contact in the US each year, only 47 people are killed as a result.
It's unclear whether the cause of death was the lightning strike or the subsequent crash.
In addition, 16 per cent of the average lightning fatalities in the US happen in Florida.