Mrs Merkel began to tremble at a televised ceremony to formally appoint a new justice minister as she stood next to German President Frank-Walter Steinmeier. In a video, the chancellor looks infirm, standing next to German President Frank Walter-Steinmeier.
She was attending a farewell ceremony for Justice Minister Katarina Barley, who is leaving to become a lawmaker in the European Parliament, when the incident occurred.
The 64-year-old attempted to try and control the shaking, which went on for about two minutes before subsiding, by folding her arms.
Merkel's spokesperson told CNN that the chancellor is "fine".
Last Tuesday, Angela Merkel was seen shaking repeatedly as she stood next to Ukrainian President Volodymyr Zelensky during a red-carpet ceremony outside the chancellery, while a military band played their national anthems.
Merkel set off to Japan a few hours later for the annual summit of the Group of 20 global powers.
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There were brief concerns about her wellbeing in 2014 when she was taken ill during a television interview.
Merkel was offered a glass of water, but passed. During that period there was no sign then of any health issues, according to the Associated Press. She has said she will leave politics at the end of her term, in 2021.
Earlier that same year, she had fractured her pelvis while cross-country skiing in Switzerland and was ordered to cut back her schedule dramatically and stay in bed as much as possible for three weeks.
She gave up the leadership of her center-right party after a pair of poor state election performances that followed a rocky start to her fourth-term government.
She is Germany's third-longest serving post-war chancellor.