The University of North Carolina-Charlotte, founded in 1946, is one of the largest universities in the state with over 24,000 undergraduate students now in attendance.
Local media reported two people suffered life-threatening injuries, while another two were being treated for less serious wounds.
Spenser Gray, a junior, said she was in a campus building near where the shooting happened watching another student's presentation when they were alerted to the shooting.
Monitor email and http://emergency.uncc.edu.” A second tweet sent 15 minutes later told students that the school remained on lockdown.
The unnamed suspect is now in custody.
About three hours after the shooting, Baker said all university buildings had been searched and secured and that students who live on campus could return to their dormitory halls. Multiple media outlets and reporters are now identifying the suspect as 22-year-old Trystan Andrew Terrell, a history student.
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Families of the deceased victims are being notified, and university staff are with those who are injured. School officials couldn't be reached for immediate comment Tuesday evening.
Campus Police Chief Jeff Baker said authorities received a call around 4:40 p.m. that a suspect armed with a pistol had shot several students.
Vi Lyles, the mayor of Charlotte, tweeted that news of the shooting was shocking.
Ari Seal, a senior PhD student, says he was in the campus gym when the active shooter announcement came over the loudspeaker.
Rep. Richard Hudson, who represents North Carolina's 8th Congressional District, issued a statement following the shooting at UNC-Charlotte: "Renee and I are heartbroken to see this violence in our community and at my alma mater", Hudson said.
Medics confirmed two people were killed in the shooting.