When asked if Itoje could recover in time to play a part this weekend, Mitchell said: "Definitely, he's certainly progressing really well".
"Right now, he's not fit for Saturday and I am not looking beyond that".
We just seemed to get in a street fight and Wales are a tough outfit.
A Welsh fan delights in watching the win over England.
Eleven wins from 11 and a player pool which allows Gatland to field a back-row of Justin Tipuric, Ross Moriarty and Josh Navidi, despite missing Taulupe Faletau, Aaron Shingler, Ellis Jenkins, James Davies and Dan Lydiate through injury, means Wales have rarely been in better shape.
Their route to Cardiff has been a contrasting one, with England claiming a maximum 10 points in seeing off Ireland and France, while Wales triumphed efficiently - rather than spectacularly -against Les Bleus and Italy.
"They got what they deserved, ultimately", Johnson admitted not long after the final whistle sounded.
James Harden accuses National Basketball Association ref of 'personal' vendetta
The rest of the way, they hit just 36.4 percent on field goals, 3-of-18 beyond the arc and did not even attempt a foul shot. The calls took away Houston's best player and resulted in two turnovers during a close part of the game.
When Wales did get close to England's line the visitors' defence held firm and speedy wing Jonny May showed there was more to their much-talked about kicking game than grubbers behind the back-line with a superb chip and sprint down the left touchline to clear a potentially unsafe situation on the stroke of half-time. For the first time this year they came under ferocious, sustained pressure and they found no-one who could come to the rescue.
England were outstanding in the first two games.
Wales are the favourites for the 2019 Guinness Six Nations, with their win over England putting them in pole position for the remainder of the championship.
Captain and totem Alun Wyn Jones called it "a nice day".
"They (England) have started really strongly (against Ireland and France), so we have got to be able to weather the storm".
Some have doubted Gatland in the past and his ability to turn Wales into Six Nations contenders. England. Not massively, but they are expected to win.
"We've had a record of being pretty good in them". Jonny May, 10. Owen Farrell (captain), 9.
Wales in Cardiff is a substantial hurdle to overcome, but if England silence the dragon's roar then their already strong World Cup prospects will move to another level. Gareth Anscombe had landed all three of his penalties but he had also kicked poorly from hand and struggled to escape the shackles of England's rush defence.
Forwards: L Cowan-Dickie (Exeter Chiefs), T Curry (Sale Sharks), E Genge (Leicester Tigers), J George (Saracens), N Hughes (Wasps), G Kruis (Saracens), J Launchbury (Wasps), C Lawes (Northampton Saints), B Moon (Exeter Chiefs), B Shields (Wasps), K Sinckler (Harlequins), B Vunipola (Saracens), H Williams (Exeter Chiefs), M Wilson (Newcastle Falcons).