Salah will now hope he can recover in time for the 2018 World Cup-Egypt's first World Cup since 1990.
"It's a serious injury, a really serious injury", Klopp told the media after his side's loss in Kiev.
Egypt's Salah and Spain right-back Dani Carvajal are both now in a race to be fit for the FIFA World Cup in Russian Federation next month.
The official Twitter account of the Egyptian team, @Pharaohs, posted a picture of Salah with the caption: "Get well soon @MoSalah".
But Egypt and Liverpool fans have recieved the good news that the X-ray shows no lasting tissue damage. It's either the collarbone or the shoulder itself.
The 25-year old Salah was substituted by Adam Lallana, who has played only 16 minutes since March because of injury.
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I am sure, if I was a guessing man, they will have spoken between the club and manager. I think that after two years the club know me very well.
Honestly, I think it's a nightmare. "It doesn't look good, that's it", the German tactician added.
Salah scored 10 goals in the Champions League this season, but the closest he went in the final was a blocked shot before his early exit.
Mohamed Salah was forced off through injury in the Champions League final.
Egypt begin the World Cup against Uruguay on June 15 before facing hosts Russian Federation and Saudi Arabia in Group A.
Bob Bradley will be more than an admirer as he watches Egypt play in the FIFA World Cup in Russian Federation next month.
"Unlike Liverpool's previous opponents in the competition, Real Madrid's defenders have far more speed to cope with the counter-attack".
Sadly, we were denied that titanic match-up as Salah was forced off and it was impossible to not feel a pang of sadness for the Egyptian as his eyes flooded with tears.