De Bruyne said he still has belief City can turn the tie around but admits it will take something special at the Etihad next week to make it happen.
"It's not impossible, it's hard".
"It would be nice, obviously", the 26-year-old Belgium global added. "But obviously they are big favourites now". You never know. The way this team plays, everything is possible.
"You can not say enough what an unbelievable season De Bruyne has had", Given told Sky's Premier League Daily.
"I think everyone in the dressing room are just normal guys".
Liverpool's players were spurred on by the raucous atmosphere at Anfield on Wednesday night, and De Bruyne is hoping his side will experience similar in front of their own fans next week. We have a lot of confidence in our qualities so we'll see. It's hard because the circumstances are different but we will be up for it.
Moscow says United Kingdom must recall over 50 more diplomats from Russian Federation
She is now in a "stable" condition - with the BBC reporting that she was conscious and talking. This includes the USA under President Donald Trump, who Putin had hoped would improve ties.
Liverpool issued a public apology to their opponents and have said they "cooperate fully with the authorities" to identify the supporters involved. Hopefully we can have the same on Tuesday. We tried to do everything in our power to win, to go through, but we'll see.
The Egypt global has scored 37 goals in 42 appearances across all competitions, and equalled a record held by Cristiano Ronaldo and Robin van Persie on Saturday when he scored in his 21st game of the Premier League season to give the Reds a 2-1 win at Crystal Palace.
De Bruyne says City were not fazed by Liverpool fans pelting their team bus with missiles on the way to Anfield.
"I already saw (things like this) before". Hopefully we can do well and win it.
Salah is likely to jostle with City midfielder Kevin de Bruyne for the Professional Footballers' Association Players' Player of the Year award.
"Since I came here, he's been unbelievable, he helped my game in a lot of ways".