But the Reds boss is confident his side can rise to the challenge and provide a quarter-final tie to remember.
Liverpool will have a whopping £250m to spend in the summer transfer window, according to former Reds star Micky Quinn.
"Finish the game with 11 - that'd be cool", he said.
"We know it's hard".
"We know they are beatable, definitely, but this is a different game". Actually that was clear before, but they are the favourites. We want to give him more assists.
"We will see", he said when asked if Aguero could return at Anfield.
Having first gone head to head with Borussia Dortmund and Bayern Munich, the friendly rivalry between Klopp and Guardiola has its biggest stage yet as Liverpool face City in the Champions League quarter-final first leg tomorrow.
Lindsay Lohan's 'Grand Theft Auto' suit is on the road to nowhere
The GTA V character in question, Lacey Jones , described herself as an "actress slash singer" and the "voice of a generation". After that, an appeal was filed to try and get the lawsuit up and running again, but this week, the request was denied.
Mohamed Salah's latest showstopper came six minutes from time against Palace, converting his 41st goal of the season for club and country consummately - perhaps making the difference between a struggle for the top four and a serene domestic run-in.
The England worldwide was able to leave the pitch without the aid of a stretcher but Klopp is anxious for Lallana, who only recently returned from a long-term thigh injury.
"I think the moment you see it is Mo (on the ball) you feel good".
"But I'm not going to be sitting here and suggesting the only reason we came away yet again with another defeat is because the referee didn't send one of their players off".
Another record comes in the form of most games scored in during a Premier League season. "That is why he got the next penalty at Liverpool and missed it [against Huddersfield], so that was not too good!"
"So this is not one game, Liverpool. If you deliver in a situation like this, what can happen to you then?" The result is, most of the time, the effect of what you have done. With so many injuries, Palace need Christian Benteke to play significantly better.
"I'm not going to say: 'Don't be happy, don't dream to win the league.' I won't say that because our opponents would say the same if it was the opposite". Germany in 1990 didn't celebrate the World Cup like this! There will be many more tests to come, but so far he has looked comfortable in nearly all of them, giving every reason to think he is money well spent. "Yes, that was really pressure!"