Ex-Manchester United and England defender Neville lambasted Guardiola's decision to name six substitutes for last weekend's 1-1 draw at Burnley, arguing the final allocated spot on City's bench should have gone to a youth team player.
But also took a fresh dig at Neville by making a disparaging reference to his disastrous four-month spell as manager of Valencia in 2016.
Guardiola said at the time that he simply did not have enough players available to name a squad of 18, and that the youth team had played the night before, meaning none of the players would have been able to travel.
"This guy, the pundit, he has to know my job is serious, it's not a joke, never is it a joke".
"If you are an academy manager or reserve team manager at Manchester City you must think "I am wasting my time".
"Management is not a book where every time you do the same things", added the Catalan.
"I wished they would have put a slow still of Kevin De Bruyne's tackle and studs on Jazz Richards", said Warnock, who believes his side suffered a backlash due to a lack of other action on the day they faced the runaway Premier League leaders.
"And of course the prestigious pundit can say whatever he wants".
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"It's not a book where you have to follow the rules". Pep was clearly made aware of Neville's strong criticism of his decision.
'David Silva and John Stones were not fit.
Guardiola was furious after his side's 2-0 fourth-round win on 28 January when Sane suffered ankle ligament damage from a awful Joe Bennett tackle.
'It was the first time in my life and an exception.
The Algerian was on strike after being denied a late move to the Etihad Stadium, but is in contention to face his potential suitors.
Meanwhile, Guardiola hopes Riyad Mahrez plays against Manchester City tomorrow after returning to training with Leicester.
"In all transfers, the clubs call the clubs, it's simple like that".
Manchester City have written to Mike Riley, head of professional referees organisation PGMOL, to request a meeting regarding some of the tackles their players have suffered in recent weeks.