De Gea has been United's most consistent performer over the last few years and firmly established himself as one of the world's best goalkeepers. Additionally, Jesse Lingard has been terrific this season and has scored eight goals in the last 10 games, so backing him to net first could be a good outside bet.
On a more positive note, Antonio Valencia is set to make his return from injury after completing the training camp in Dubai.
He will watch this game from the stands and take over on Tuesday. Mourinho's side, meanwhile, are now three points clear of third-placed Liverpool in the table.
The relegation-threatened side face Manchester United at Old Trafford tonight. United are understood to have moved ahead of Pep Guardiola's Manchester City in the race to sign the Chilean due to their apparent willingness to either pay a higher £35m ($48.1m) fee or include a player as a makeweight.
The Red Devils will host Stoke City, a team that already gave the team some problems during the first round of action.
Ford Mustang Bullitt: Five neat features on the revived Steve McQueen classic
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He recorded back-to-back promotions to the Premier League with Norwich before keeping Villa in the Premier League against all odds in the 2013/14 season. There can be no excuses, however, as they approach at a vital run of matches in the top flight.
Derby boss Gary Rowett and Espanyol manager Quique Sanchez Flores were also reportedly on the club's managerial shortlist. His appointment was not exactly met by excitement from the Stoke fans, and the former Wolverhampton Wanderers boss has a lot of work to do in the coming weeks.
He could give a debut to Austrian global Moritz Bauer after the right-back joined last week following Hughes' dismissal.
With 30 minutes left on the clock, Sobhi replaced Eric Maxim Choupo-Moting hoping to reduce the deficit for his side.