Reyes' boyhood club Sevilla confirmed the news on social media on Saturday.
Reyes, who had played for some of the biggest clubs in Europe including Premier League team Arsenal, was in a vehicle traveling on a road in his hometown of Utrera, near Seville, when it crashed just before noon on Saturday.
"He had a glittering career and won numerous honours wherever he played and I am shocked and saddened that his life has been so tragically cut short".
There will be a moment's silence before kick-off of the Champions League final as a mark of respect for Reyes. "He will remain forever in our hearts".
UEFA and European football is deeply saddened to hear of the tragic death of footballer José Antonio Reyes in a vehicle accident at the age of 35.
The Spanish Football Federation (RFEF) has announced that the seven Segunda Division games scheduled to be played on Sunday would now be held on Tuesday evening following Reyes' death.
Reyes shot to prominence after joining Arsenal in 2004, transferring from Sevilla.
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"Broken. Shattered", wrote Ramos.
The Spaniard was now playing for Spanish second division side Extremadura.
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Jose Antonio Reyes has been described as a "wonderful player, superb team mate and exceptional human being" after the 35-year-old died in a auto crash.
Monchi, who overlapped with Reyes as a player at Sevilla and is now the club's director of football, also tweeted his sadness and referred to wingback Antonio Puerta, who died of a cardiac arrest playing for Sevilla in 2007.
He was sent off in extra time of the 2005 FA Cup final win over Manchester United and also lifted the Community Shield during his time at Highbury.
Reyes played 21 times for Spain between 2003 and 2006, scoring four goals.