Eric Bledsoe scored a game-high 27 points while Khris Middleton added 24 points and eight assists for Milwaukee.
There's a chance Griffin (knee injury) could make his series debut Wednesday night, but even if he does, the Pistons will have their work cut out for them against the Bucks. Antetokounmpo leads the Bucks averaging six.
After knocking down 9-of-23 from beyond the arc in the first half, they managed just 3-of-13 from deep the rest of the way.
A quick guide to North Okanagan Easter egg hunts
Gather at 10 a.m., egg hunt begins at 10:30 a.m. sharp, followed by prizes, snacks and refreshments. The 13th Annual Blind River Easter Egg Hunt will take place at Town Park on Saturday at 11 a.m.
Griffin picked up his second technical foul in as many games Wednesday night as he argued with officials while wearing a suit on the bench. Detroit has allowed three players from Milwaukee to score at least 20 points while no one from their side reached that mark. His aggression set the tone for Milwaukee, who outscored Detroit 35-17 to take a 17-point lead into the fourth quarter. Antetokounmpo's 3-pointer on the next trip down the floor put the Bucks ahead for good. Milwaukee ranks seventh in the National Basketball Association with 26 assists per game. The team was going to struggle remaining competitive with Griffin on the court.
What do the Pistons have to lose at this point?
Milwaukee Bucks: Sterling Brown's playoff coming of age: Rob Gueldner dove into the recent play of Bucks second-year wing Sterling Brown and how he's showcased his entire array of talents since being inserted into the team's starting lineup late into the season.