Toby Alderweireld went close to doubling Tottenham's advantage from a Christian Eriksen corner moments later, but Burki was on hand to keep his header out.
Midfielder Harry Winks, who was the flag-bearer for Spurs' Champions League tie against Inter Milan in 2011, admits it is extra special to him and hopes this sends a message to the rest of Europe.
Spurs boss Pochettino described the match as a game of two halves, but the Argentine believes his side's confidence shone through in second to help his team pull away.
Mauricio Pochettino's side struggled in the opening 45 minutes but, as has often been the case in the Champions League this season, they found the net in the second period.
Belgian Vertonghen notched his first goal in the Champions League with a well-timed volley in the 83rd minute after he had set up forward Son for a 47th minute lead.
Newborn rescued from storm drain
First responders were alerted to the emergency when residents reported hearing the cries of a young baby coming from the drain. Eyewitnesses at the scene described the dramatic moments they discovered the infant trapped inside the drainage system.
"The only thing I can think of is we just didn't come out with the same mentality".
Pulisic will be play for Chelsea next season, having signed for them in the January transfer window before being loaned back to Dortmund for the remainder of the season. When they got on top this time, they tightened their grip.
"It was a massive victory for us and the players deserve all the credit".
"Today we won 3-0".
"Unfortunately, we just weren't locked in on their crosses and they were able to score off three crosses, and we've got to work on that". The best defence is when you attacking and the team from Germany will be wide open for the picking, as they search for three goals to equal and four goals to overcome the almost impossible deficit. "But it's a great result, hopefully we can progress and who knows where we can go?"