The new clarifications 'make it clear that challenges like the Tide pod challenge, that can cause death and/or have caused death in some instances, have no place on YouTube, ' the company wrote in a blog post.
"Our Community Guidelines prohibit content that encourages risky activities that are likely to result in serious harm, and today clarifying what this means for unsafe challenges and pranks", the company said in a statement in the Frequently Asked Questions - FAQ - section of their website.
YouTube added that its policies also extend to pranks with a perceived danger of serious physical injury.
"Content that features a child participating in unsafe challenges that pose an imminent risk of injury or bodily harm are also not allowed on YouTube".
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Meanwhile, Netflix has also warned users against doing the Bird Box challenge.
YouTube has moved to ban videos that depict unsafe activity that could cause injury or death - like the "Bird Box" and "Tide Pod" challenges, which were both very popular on the site a year ago.
After receiving demands from the community to not allow these types of risky videos, YouTube has announced that it is banning all harmful challenges and pranks. Some people suffered severe burns as a result of the challenge. Do you think there are too many risky pranks on YouTube?
YouTube said it worked with "child psychologists to develop guidelines around the types of pranks that cross this line", giving examples like the fake death of a parent or shaming for mistakes.
While playful challenges or pranks have become raging trends online, with video shared at YouTube or Facebook, some "memes" have put people in jeopardy.
YouTube also tightened rules on creators who violate its guidelines outside of videos, announcing a policy under which it will apply strikes to users who "egregiously" violate rules in video thumbnails, or links to external content. Any violations will still be removed, but channels won't receive a strike against them during this time.