Shakhtar are third in the group G, two points adrift their visitors, Lyon but will be through if they win otherwise will drop to the UEFA Europa League round of 32 if they draw and Hoffenheim do not gain victory.
The clean sheet was the key, however, and Liverpool survived a huge scare in injury-time when goalkeeper Alisson made a crucial save from Arkadiusz Milik in a rare Napoli opening. "Mo Salah scored an unbelievable goal and I have no idea how Alisson made a save like this, it was wonderful".
4 - Riyad Mahrez has assisted more goals (four) than any other player in the Champions League this season, setting up a team-mate once every 75 minutes.
Juventus will be group winners if they beat Young Boys in Switzerland, but Manchester United will travel to Valencia in the hope that they can beat Los Che and also hear of an upset in Bern.
Klopp added: "It was not only one save". He had a lot of things to do tonight. When he comes out for crosses he is outstanding. And, yes, that save was just incredible. We had big chances and you're going to be frustrated when you miss those chances, including myself.
"For me it isn't easy to win against Guardiola but we need to find this kind of motivation and we need to play with the level of determination in the other matches otherwise it's useless to win a match like this".
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Infinity War and that ending were absolutely bonkers, and left many fans shocked and clamoring for answers. We also see an angry and now violent Hawkeye which is now converted into the new hero Ronin.
Klopp was left delighted with the performance from his side, who are now unbeaten in their last 19 European matches at Anfield.
"I am really proud of the boys". Our offensive, defensive and pressing was some of the best I ever saw.
"What we have learned so far is we work really hard and we are difficult to play". Yes, we could have scored more often but the 2-0 doesn't help a lot.
"We gave everything, but it didn't work out and we're sad", the midfielder told his official website after Tuesday's 1-0 defeat to Liverpool. You could see this little bit of relief and then Napoli was there.
Andy Robertson could make his 50th appearance for Liverpool in this game.
"We knew at half-time we couldn't change the tactics and sit deeper".
"That's the first real question we've got to ask about Koulibaly, the centre-half".
Should Paris Saint-Germain draw in Belgrade and the Reds win at Anfield by any scoreline, Liverpool will finish top of the group by virtue of having the best record amongst the three teams. "It is a big opportunity for us and we will try everything to put it right", Klopp said this week.