The visitors - coached by Kelvin Davis in this match - hit the woodwork three times before Charlie Austin netted a stoppage-time consolation, but three soft goals had already killed off a Southampton side who are now only kept off the foot of the table by goal difference.
A new coach will take the team tomorrow, and the agreement was signed two and a half years.
'I can guarantee you that when you see us playing in the summer it will be different than when you see the team now, ' he said. It's a bit back to the roots for me, a year ago was maybe easier because I had a fantastic Champions League team, and we were on a very high level tactically.
"This managerial change offers us a fresh start and, very quickly, Ralph emerged as our ideal candidate".
"The first target is to get out of this relegation zone".
"Hugo Lloris was man of the match and that's something I'm disappointed about", he added.
"I'm delighted to be back in the team and to get the three points".
Spurs take advantage of rivals' slip-ups
Southampton's next fixture is at relegation rivals Cardiff.
The new boss watched his team lose 3-1 to Tottenham at Wembley on Wednesday and quickly noticed one area of concern - the defence.
"In history there were a lot coming out from there and players coming out of the youth academy and that's the goal for the future and perform with these guys, develop and maybe one or the other can help us do it better in the Premier League". "We were sitting in the football school together and made our pro licence together and I was always a fan of his football".
Southampton have won just nine points from their opening 15 games this season.
Last season under Hasenhuttl, Leipzig played in the Champions League for the first time and subsequently reached the Europa League quarter-finals.
After Eriksen's low free-kick was well saved by McCarthy, Moura fired home from the resulting corner at the second attempt for his fifth Premier League goal of the campaign.
"We have been aware of Ralph since his days at FC Ingolstadt, where he showed the qualities that we believe we need at the club", said Krueger.
Crackdown on Italian mob prompts dozens of arrests in Europe
The "Ndrangheta is seen as the most powerful Italian mafia organization, trumping Sicily's Cosa Nostra and Naples" Camorra. The investigation also involved operations in the South American country of Suriname.