The goal of their visit is to strengthen diplomatic ties between Ghana and the United Kingdom and would highlight key themes within the Commonwealth of Nations.
"The UK and Ghana's shared history and common values form the basis of our enduring friendship".
The royal couple is expected to visit Ghana before ending their trip in Nigeria on November 6 - 8.
Britain's Prince Charles, Prince of Wales (R) is welcomed by Gambia's President Adama Barrow (L), upon his arrival at the airport in Banjul, for an official visit.
Prince Charles and Camilla then travelled to the Coco Ocean Hotel for a performance by a Kora ensemble, a West African 21-string lute-bridge-harp, and a "cultural dance and acrobatic display in the tradition of the Kayorn Kalorn, Banjul, Kabakel and Fula Juboo tribes".
The Royal visit to Ghana formed part of a week-long tour of West Africa to strengthen ties with the Commonwealth nations.
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A visibly elated Prince Charles was seen in a hearty chat with President Akufo-Addo about the pictures, which showed him in military uniform inspecting a guard of honour in Ghana.
Charles' comment came during a welcoming ceremony attended by Gambia's president Adama Barrow, whose shock election victory in 2016 brought an end to the authoritarian regime of former leader Yahya Jammeh. This will be the Duchess of Cornwall's first visit to Ghana.
The couple attended a reception for Chevening alumni, which is a programme that helps Commonwealth students to study in the United Kingdom through scholarships and fellowships, Gambian Commonwealth athletes and High Commission staff. The event would be attended by senior dignitaries, British nationals, a cross-section of Ghanaians and prominent figures from business, arts, culture and the media.
He will also meet with key players in Ghana's cocoa industry where he will discuss innovative ways to sustain one of the country's most profitable resources.
The visit will throw the searchlight on a number of important commitments made by the Commonwealth Heads of Government during the last Commonwealth summit.