"Today, Sunday 7 October, (at) the Interpol General Secretariat in Lyon, France received the resignation of Mr Meng Hongwei as President of Interpol with immediate effect", Interpol said in a statement this evening. It did not say why.
On Sunday, a statement from China's ruling Communist Party said Meng was "under the monitoring and investigation" of China's new anti-corruption unit, the National Supervision Commission, for suspected serious violations of state law.
"Public Security Ministry Vice Minister Meng Hongwei is now under investigation by the National Supervisory Commission for suspected violations of law", the Chinese anti-graft body said in a brief statement on its website.
Grace Meng detailed the chilling final exchange of messages with her husband, Meng Hongwei, to reporters in the French city of Lyon, where Interpol was based. Grace also said four minutes before Meng shared the image, he had sent a message saying: "Wait for my call".
She added, "Although I can't see my husband, we are always connected by heart".
Grace Meng, the wife of missing Interpol President Meng Hongwei, who does not want her face shown, spoke in France on Sunday.
After China admitted it had Meng in custody, the paper quoted Beijing-based political commentator Zhang Lifan, who said: "I guess something urgent must have happened". "For the husband whom I deeply love, for my young children, for the people of my motherland, for all the wives and children's husbands and fathers to no longer disappear".
She says she has had no further contact with him since the message that was sent on September 25.
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Interpol has said it is concerned about his apparent disappearance and has made inquiries with China.
"His job is very busy", she said.
The Hong Kong newspaper said Meng was "taken away" for questioning upon landing in China last week by what it said were "discipline authorities".
Meng is China's vice minister of public security.
Meng, 64, had lived with his wife and two children in France since being elected Interpol president in 2016.
China has been cracking down on corruption under President Xi Jinping. He is a senior member of the Communist Party.
She wouldn't speculate on her husband's current whereabouts.
Local French media reported that Mr Meng's wife had issued a brief statement from a hotel in Lyon, in which she expressed her concerns over the situation. Officials under suspicion often disappear into the party's investigatory body, which can hold them for months without releasing information or providing them with legal counsel.