Joe Manchin is facing a hard re-election campaign in West Virginia, a traditionally Republican state that Mr Trump won by a landslide. Democrats hope that the roll call, exactly a month from elections in which House and Senate control are in play, will prompt infuriated women and liberals to stream to the polls to oust Republicans.
"We will be ill-served in the long run if we abandon the presumption of innocence and fairness, tempting though it may be", she said.
If Kavanaugh joins a five-member bloc of Republican judges that makes it more hard for women to get an abortion, or interferes with the Environmental Protection Agency's ability to control air pollution that comes to ME from the Midwest, or protects President Trump from legal action, Collins will own a share of the blame.
Collins said Christine Blasey Ford's dramatic testimony to the Senate Judiciary Committee last week describing Kavanaugh's alleged 1982 assault on her were "sincere, painful and compelling".
The president told reporters that Kavanaugh is going to do a "great job" as he left the White House fora rally in Topeka Kansas.
"My heart goes out to anyone who has experienced any type of sexual assault in their life", Manchin said. Maybe Kavanaugh will defy the experts and not join a series of 5-4 decisions like Citizens United, the 2008 case that eliminated the spending limits for electioneering by corporations, or last year's Janus decision, which overturned a 40-year "settled law" precedent governing public-sector unions' ability to collect fees.
Another group of protesters stormed towards the doors of the nearby Supreme Court building with raised fists. Mr Kavanaugh has denied all the allegations. "I look forward to his confirmation to the Supreme Court".
A townhouse near the Washington residence of Republican Senator Susan Collins, whose backing for Kavanaugh helped get him over the line on Saturday, flew the flag of her home state ME upside down in protest. She told reporters Friday that Kavanaugh is "a good man" but maybe "not the right man for the court at this time".
Watch live: Senate vote to confirm Brett Kavanaugh to Supreme Court
The timing of the final vote is also up in the air. The move did not impact the overall outcome of the vote, but it allowed for the margin to be the same as it would have been if Daines had been there to participate and prevented a situation where Daines would have to fly back Saturday to cast a vote to ensure the result.
The confirmation comes after weeks of drama and controversy stemming from allegations made by Dr. Christine Blasey Ford that Kavanaugh sexually assaulted her at a party in the early '80s when they were both in high school. Two other women also accused Kavanaugh of sexual misconduct decades ago.
The 50-48 vote Saturday is a resounding victory for President Donald Trump and Senate Majority Leader Mitch McConnell, whose top mission has been to engineer a rightward turn in the federal judiciary, especially the nation's highest court.
With Republicans controlling the chamber 51-49, one Republican voted to stop the nomination, one Democrat to send it further.
President Trump beamed over Kavanaugh's confirmation as he belittled the demonstrators.
The vote occurred against a backdrop of smoldering resentment by partisans on both sides.
By a vote of 50-48, the Senate gave a lifetime job to Kavanaugh, 53, after weeks of fierce debate over sexual violence, privilege and alcohol abuse that convulsed the nation just weeks before congressional elections on November 6.
She wants to make clear, however, that her support of Kavanaugh does not mean she does not believe in the validity of the #MeToo movement.
U.S. visas denied to same-sex partners of diplomats
Secretary of State Mike Pompeo has said he opposes same-sex marriage , but he has promised to treat all employees with respect. The new policy grants some limited exceptions for diplomats representing countries where same-sex marriage is illegal.