The German tactician believes City have the strength in depth to cover for De Bruyne, who was instrumental in City's double-winning success last season.
Speaking before City's league match against Huddersfield Town on Sunday, Guardiola said: "We are going to try to do our best, whether he is coming back at the start of December or end of November to be there (at the top of the table)".
"This can happen because they build an awesome stadium for Tottenham Hotspur, sometimes there are delays".
"I don't know, we are going to adapt if we can adapt and of course we are going to think of ourselves as well, and of course the Premier League".
"I think somebody who thinks like that, about a situation like that, is an a**hole, to be honest", Klopp told Sky Sports.
"I remember when I joined in 2011; the Premier League has come on leaps and bounds since then - the pace of the Premier League and the games we're playing in are so quick nowadays".
"But I'm a manager for what happens on the pitch and that's enough".
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Manchester City boss Pep Guardiola suggests that a knee injury sustained by midfielder Kevin De Bruyne is partly due to fatigue.
The injury means he will miss most of the group stage of the Champions League, which starts in September, and two matches for Belgium in the new UEFA Nations League.
"He will be a big miss", he said. Last season Kevin was outstanding in all terms and of course for him and his family you never want this but you accept it's part of the game.
"Sometimes that is normal".
Guardiola endured a hard debut campaign in England after being appointed manager in 2016, finishing his first season at the club trophyless and under a lot of pressure. They (the football authorities) say "let's go" and we are in the competition.
"An injury like that is part of football and human beings have limits".
'He had a problem with his leg for the Arsenal game but he has trained good in the last two or three days'.