After a stellar 2017 season, during which she reached the Australian Open and Wimbledon finals and the US Open semifinals, Williams has now lost two consecutive first-round grand slam matches for the first time in her long career.
He quickly levelled at 3-3 today, saved four break points in the eighth game before saving four set points.
Safwat, the first man from Egypt to play in a main draw match of a major since Tamer El Sawy at the 1996 U.S. Open, said he had never even been inside of the main Court Philippe Chatrier.
She was No. 1 when she left the tour to give birth, but is now ranked No. 451.
James Blake, a former ATP Tour player who is the director of the Miami Open, said at the time that a player such as Williams deserved to have been "protected" by the WTA.
Dressed in skintight, all-in-one black bodysuit, broken up by a vivid scarlet belt, Serena captivated the French crowd from the start of the contest to its 7-6 (4), 6-4 conclusion.
Play has been interrupted at the French Open as rain falls.
"I really suffered today but it was a good test", said Nadal who had been in danger of dropping his first set at Roland Garros since his 2015 quarterfinal loss to Novak Djokovic.
Williams attended the May 19 wedding of her friend, American actress Meghan Markle, and Prince Harry.
Trump to meet Abe before 'expected' Kim summit
This came after several roller-coaster days in which Trump canceled the summit, set for June 12 in Singapore. Naval Academy, did not mention North Korea directly, but he stressed the United States' military might.
He faced Bernard Tomic in the first round on Monday and emerged with a 6-4, 5-7, 6-4, 6-4 victory in a match that lasted almost 3 hours.
Canada's Denis Shapovalov defeated Australian John Millman, 7-5, 6-4, 6-2 to move on to round two and South Africa's Kevin Anderson, seeded sixth, beat Italy's Paolo Lorenzi 6-1, 6-2, 6-4, while Britain's Kyle Edmund swept past Alex De Minaur 6-2, 6-4, 6-3.
The 36-year-old American had not competed at a Grand Slam tournament since the Australian Open in January 2017, when she was pregnant and won her 23rd major championship.
Trungelliti, a 28-year-old Argentine ranked 190th, lost in qualifying at Roland Garros and then headed home to Spain.
Another former French Open champion has exited the tournament in the first round as Stan Wawrinka lost a five-set battle with Guillermo Garcia Lopez of Spain.
Next for Shapovalov is a matchup against 70th-ranked Maximilian Marterer of Germany, a 6-1, 6-3, 7-5 victor against Ryan Harrison of the U.S.
Former top-ranked player Victoria Azarenka has bowed out of the French Open in the first round, beaten 7-5, 7-5 by Katerina Siniakova.
Other winners on the first day of Roland-Garros included Japan's Kei Nishikori, the second-seeded German Alexander Zverev and France's Gael Monfils.
Muguruza, who claimed the title in Paris two years ago, advanced to the second round 7-6 (0), 6-2.
Jelena Ostapenko was dethroned as the French Open champion by the 66th-ranked Kateryna Kozlova on the first day of the French Open.
Sloane Stephens ended her grand slam drought since winning the US Open last summer with a 6-2, 6-0 win over lucky loser Arantxa Rus of the Netherlands on the new Court 18.