Arsenal's Aaron Ramsey scores their third goal against CSKA Moscow April 5, 2018.
In the last round Atletico steamrolled Lokomotiv with an aggregate 8-1 win, from five goals away at the RZD Arena, and the expectation is there to produce a similar result against their Portuguese opponents.
Germany forward Mesut Ozil also shone as Arsenal's crisp one-touch passing repeatedly carving open a cumbersome Russian defence.
Ramsey, who hit the woodwork in the second half when Akinfeev made several fine saves, was delighted.
Koke put his side ahead on just 22 seconds, slotting home after Diego Costa robbed dawdling Sporting defender Sebastian Coates. If we had to play against Bayern Munich they would say it's an impossible game but if it was against Astana they would say it's easy, but the truth is you have to play every game and we always try to do our best to qualify for the next rounds.
Thiago's late header seals Bayern win against Sevilla
Who is the most likely team to win the Champions League? We didn't use the space in midfield and the tempo wasn't high enough. The visitors were in control in what seemed like Sevilla's undoing in the 2-2 draw with Barcelona in La Liga on Saturday.
"I like to make those late runs into the box, I had plenty of opportunities but I am glad I was able to contribute to the team", he told BT Sport.
Next up for Atletico is Sunday's derby against Real Madrid at the Santiago Bernabeu, where victory for Simeone's men would strengthen their grip on second place in LaLiga behind Barcelona.
And Antoine Griezmann added a second after taking advantage of another Sporting error.
Abuser Dynamo Kyiv, Lazio thanks to a shock cut in the second half with two goals in Rome beat RB Salzburg.
The hosts led after eight minutes through captain Senad Lulic, but Valon Berisha equalised with a penalty.
Elsewhere, RB Leipzig lead French giants Marseille 1-0 as German worldwide striker Timo Werner got the only goal for the Bundesliga side.