"I'm not going to talk about Real Madrid and [Zinedine] Zidane's decisions", said Lopetegui.
"Here I have the confidence of the coach, in Madrid maybe I have not won it".
A regular fixture on the national teamsheet, yet one that is often on the fringes of the Real Madrid starting XI - Isco admits that he is not as optimistic when it comes to the club level, but hopes this latest performance will give Zidane something to ponder.
"Lopetegui gives me confidence with minutes, with games", Isco said.
It remains to be seen whether Real Madrid will consider cashing in on Isco when the summer transfer window swings open, but a good display in Russian Federation could boost the sum Los Blancos feel able to ask for if clubs enquire about the 25-year-old.
Spain's Isco celebrates scoring their sixth goal and completing his hat-trick.
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"I have congratulated the players and thanked them", added Lopetegui.
Arsenal and Manchester United were the other two sides linked in the report, but a desire to play under Pep Guardiola - at least according to The Sun's source - give City the edge. "I'd be wrong to second guess the thinking of Zidane".
It was an important miss as Spain opened the scoring in the 12th minute after Andres Iniesta, making his 125th worldwide appearance, won possession and fed Asensio, whose pass picked out Diego Costa to open the scoring. "I went six months without playing as you all know, but I knew that if I started playing again I would have a chance of returning, and I'm happy to be here".
When the forward has been available he has impressed, netting 12 goals and providing seven assists in all competitions.
"This result means we have to take responsibility and take another look at who will make the final list", Sampaoli said.
It was the ideal way for La Roja to warm-up ahead of the World Cup in Russian Federation.