It was a rare moment of concern for Newport but Rodney Parade erupted six minutes later.
Toby Alderweireld has been a long-term injury casualty and although he is stepping up his recovery from that he is not deemed ready for this fixture, while injuries to Harry Winks, Serge Aurier and Erik Lamela are likely to keep them out of Tottenham's trip to Wales.
The draw is priced at 13/2 (7.50), which would see Michael Flynn's side earn a replay at Wembley.
However, Tom Owen-Evans (dead leg), Sean Rigg (hip) and Marlon Jackson are out. Joss Labadie and Matthew Dolan are not certainties for this tie.
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Amond was denied a second when Vorm pushed his volley wide and Pochettino responded to the situation at half-time by ripping up his wing-backs formation and replacing Kyle Walker-Peters with Son.
League One high-fliers Wigan produced a blistering performance to dump Premier League side West Ham out of the FA Cup with a 2-0 win at the DW Stadium. However, should Newport cause Tottenham trouble and be on the verge of an upset, Pochettino will be likely to have Kane, Ali and Son on the bench to utilise.
Newport have scored at least two goals in each of their FA Cup games this season.
Apart from one solid display against Real Madrid in the UEFA Champions League, there has been very little from the 32-year old to make him stand out.
Newport County were superb, especially in the first half, but plenty of Tottenham fan anger turned towards their out-of-sorts frontman.
An 89th-minute victor from Shawn McCoulsky set up the Exiles' first fourth-round FA Cup tie in 41 years, causing the biggest FA Cup upset of the last round. And a 3-0 victory is what we at the Hard Tackle predict for the North Londoners.